A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway
نویسندگان
چکیده
منابع مشابه
Negative regulation of Toll-like receptor signaling pathway.
TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that...
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The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream target genes, wherein the TLR-interacting adaptor molecule MyD88 recruits various signaling molecules and transcription factors. Two members of the IFN regulatory factor (IRF) family of transcriptio...
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background: m2000 is a newly designed and safe non-steroidal anti-inflammatory drug (nsaid). the aim of this study was to assess the effects of m2000 on expression levels of suppressor of cytokine signaling-1 (socs-1) and src homology-2 domain-containing inositol-5’-phosphatase 1 (ship1) proteins via toll-like receptor (tlr) 2/microrna-155 pathway. methods: hek293 tlr2 cell line and peripheral ...
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Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact with each other has not been well studied. We demonstrate here a widespread r...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.06.048